Screenwriting contest was founded in 1998
Matt Umbarger of Irvine, Calif., took the first topographic point award, worth $10,000, in the 10th annual Scriptapalooza screenwriting competition for his screenplay "The Terminals." Damian Lahey and Ian Ogden of Brooklyn, N.Y., were the second station winners for "Child in the Dark," while Los Angeles' Heather Regnier was the third place success for "Sober Living."
Scriptapalooza prexy Mark Andrushko also proclaimed 10 runners-up: "360," by Richard Nguyen-Marshall; "A Revolution in Urination," Christian Heinze; "Carnies," Dean Ward & Matt Ward; "Cedarpine Views," Mischa Ayoub; "Palmer," Cheryl Guerriero; "Soulmates," David Birkenhead; "Spring-heeled Jack," David Pardue; "The Fahey Men," Jane Holahan; "Three Rivers," Brian Loschiavo & Josh Macuga; and "Willie Francis Must Die Again," Allan Durand.
The Scriptapalooza competition was founded in 1998 to discover hopeful writers.
More info
Saturday 23 August 2008
Wednesday 13 August 2008
Nature Publication Reports On Key Role Of Bile Acids In Glucose Metabolism And Insulin Signaling
�Historically, bile acids get been
recognised primarily as natural detergents that order the absorption of
dietary lipids and cholesterol homeostasis. However, late research
advances provide grounds that bile acids have broader systemic endocrine
functions, acting as important mediators of glucose metabolism and insulin
signaling. The featured article in the current issue of Nature Reviews Drug
Discovery (Vol. 7, Number 8, August 2008) describes wherefore bile caustic receptors
are promising targets for drug development in obesity, character 2 diabetes,
atherosclerosis and other continuing metabolic disorders such as nonalcoholic
steatohepatitis.
Highlights of the article, "Targeting bile acid signal for metabolic
diseases," authored by Drs. Charles Thomas, Roberto Pellicciari, Mark
Pruzanski, Johan Auwerx and Kristina Schoonjans, include:
-- Bile acids dish as metabolic integrators, activating major
signal pathways regulated by nuclear hormone receptors including the
farnesoid X receptor (FXR) and G protein-coupled receptors (GPCRs) such as
TGR5.
-- Bile acids play a major role in lipid metamorphosis and homeostasis.
For example, bile caustic activation of FXR results in a decrease in serum
triglyceride levels.
-- The activation of TGR5 by bile acids increases energy expenditure
and reduces diet-induced fleshiness. Conversely, "knockout" animal models
engineered to lack TGR5 show a tendency towards weight gain.
-- Bile acids cause broad personal effects on glucose homeostasis, including a
decrement in gluconeogenesis (glucose synthesis by the liver). These effects
have been attributed primarily to activation of FXR. Additionally, mice
that lack FXR have impaired glucose tolerance and ar insulin-resistant.
Dr. Schoonjans, Ph.D., a group leader at the Ecole Polytechnique
Federale de Lausanne commented, "Our research efforts have exposed a
number of internal secretion effects mediated by gall acids performing on receptors such
as FXR and TGR5. This review is one of the number one to put up a comprehensive
summary of what is now known about bile acid sign and its relevance
for metabolic function. From this broad vantage point, we pot see the potential
for identifying of import new therapeutics that can address a number of
important disorders."
Dr. Pruzanski, founder, President and CEO of Intercept Pharmaceuticals,
commented, "At Intercept, we have proprietary insight into the rational
design of stiff FXR and TGR5 agonists derived from bile acid scaffolds. To
date, we have innovative our lead compound, INT-747, a first-in-class FXR
agonist, into trey ongoing Phase II trials. The innovative research existence
reported in the flow issue of Nature Reviews provides extra support
for our programs, and we look forward to reporting the advance of our
discovery and development efforts in the appropriate forums."
About Intercept Pharmaceuticals
Intercept is a clinical stage biopharmaceutical company focused on
discovering and development small molecule drugs for the treatment of
chronic fibrotic and metabolic diseases. The company's scientists and
affiliated researchers have published extensively on the office of bile acid
signal via the nuclear internal secretion receptor FXR and the G protein-coupled
receptor TGR5. These receptors are key fruit mediators of energy homeostasis and
are involved in maintaining integral functions of the liver, intestine and
kidney, organs exposed to bile
recognised primarily as natural detergents that order the absorption of
dietary lipids and cholesterol homeostasis. However, late research
advances provide grounds that bile acids have broader systemic endocrine
functions, acting as important mediators of glucose metabolism and insulin
signaling. The featured article in the current issue of Nature Reviews Drug
Discovery (Vol. 7, Number 8, August 2008) describes wherefore bile caustic receptors
are promising targets for drug development in obesity, character 2 diabetes,
atherosclerosis and other continuing metabolic disorders such as nonalcoholic
steatohepatitis.
Highlights of the article, "Targeting bile acid signal for metabolic
diseases," authored by Drs. Charles Thomas, Roberto Pellicciari, Mark
Pruzanski, Johan Auwerx and Kristina Schoonjans, include:
-- Bile acids dish as metabolic integrators, activating major
signal pathways regulated by nuclear hormone receptors including the
farnesoid X receptor (FXR) and G protein-coupled receptors (GPCRs) such as
TGR5.
-- Bile acids play a major role in lipid metamorphosis and homeostasis.
For example, bile caustic activation of FXR results in a decrease in serum
triglyceride levels.
-- The activation of TGR5 by bile acids increases energy expenditure
and reduces diet-induced fleshiness. Conversely, "knockout" animal models
engineered to lack TGR5 show a tendency towards weight gain.
-- Bile acids cause broad personal effects on glucose homeostasis, including a
decrement in gluconeogenesis (glucose synthesis by the liver). These effects
have been attributed primarily to activation of FXR. Additionally, mice
that lack FXR have impaired glucose tolerance and ar insulin-resistant.
Dr. Schoonjans, Ph.D., a group leader at the Ecole Polytechnique
Federale de Lausanne commented, "Our research efforts have exposed a
number of internal secretion effects mediated by gall acids performing on receptors such
as FXR and TGR5. This review is one of the number one to put up a comprehensive
summary of what is now known about bile acid sign and its relevance
for metabolic function. From this broad vantage point, we pot see the potential
for identifying of import new therapeutics that can address a number of
important disorders."
Dr. Pruzanski, founder, President and CEO of Intercept Pharmaceuticals,
commented, "At Intercept, we have proprietary insight into the rational
design of stiff FXR and TGR5 agonists derived from bile acid scaffolds. To
date, we have innovative our lead compound, INT-747, a first-in-class FXR
agonist, into trey ongoing Phase II trials. The innovative research existence
reported in the flow issue of Nature Reviews provides extra support
for our programs, and we look forward to reporting the advance of our
discovery and development efforts in the appropriate forums."
About Intercept Pharmaceuticals
Intercept is a clinical stage biopharmaceutical company focused on
discovering and development small molecule drugs for the treatment of
chronic fibrotic and metabolic diseases. The company's scientists and
affiliated researchers have published extensively on the office of bile acid
signal via the nuclear internal secretion receptor FXR and the G protein-coupled
receptor TGR5. These receptors are key fruit mediators of energy homeostasis and
are involved in maintaining integral functions of the liver, intestine and
kidney, organs exposed to bile
Wednesday 6 August 2008
Bowling For Soup
Artist: Bowling For Soup
Genre(s):
ROck: Alternative
Punk
Pop: Pop-Rock
Rock
Discography:
Great Burrito Extortion Case
Year: 2007
Tracks: 14
Rock On Honorable Ones!!!
Year: 2005
Tracks: 15
Goes To The Movies
Year: 2005
Tracks: 15
A Hangover You Don't Deserve
Year: 2004
Tracks: 18
Drunk Enough To Dance
Year: 2002
Tracks: 18
Let's Do It For Johnny!!
Year: 2000
Tracks: 13
Tell Me When to Whoa
Year: 1999
Tracks: 7
Punky mightiness pop up outfit Bowling for Soup was formed in 1994 in Wichita Falls, TX, featuring headliner vocalist/guitarist Jaret Reddick, guitarist/vocalist Chris Burney, bassist Erik Chandler, and drummer Gary Wiseman. The group real began to jell in 1997 when a big touring schedule helped let out their fan base and landed them opening musca volitans for across the nation large punk and ska bands. The following yr, they recorded a debut EP for the local FFROE label, titled Tell Me When to Whoa!; by now, their base of trading operations of trading operations had been touched to Denton, TX, the site of the label's headquarters as good. Later in 1998, Bowling for Soup issued their first full-length album, John Rock on Honorable Ones!!!; both it and its predecessor proven popular or so the state (Honourable Ones sold o'er 10,000 copies solitary) and the ring complete up grading a allocate with Jive/Silvertone. For their 2000 major-label debut, Let's Do It for Johnny!, Bowling for Soup re-recorded some of the charles II Herbert Best songs from their indie records and added a few young tracks, including lead unmarried "The Bitch Song" and a address of Bryan Adams' "Summer of '69." Two long time later on, the roach released Drunk Enough to Dance, and nabbed a Grammy nomination for the single "Girl All the Bad Guys Want." Holdover You Don't Deserve followed in 2004, and BFS landed some other hit single in "1985," which helped propel Holdover to number 37 on the Billboard deuce hundred. Bowling for Soup returned in 2005 with Goes to the Movies, on which they tackled versatile moron box and film theme songs. The Great Burrito Extortion Case followed in the fall of 2006, spearheaded by the live single "High School Never Ends."
Roberto Carlos Nakai and Peter Kater
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